Cdkn1a
نویسندگان
چکیده
Comment on: Aravinthan A, et al. Cell Cycle 2014; 13:1489–94; PMID:24626178; http://dx.doi.org/10.4161/cc.28471 Luca Valenti* and Paola Dongiovanni; Department of Pathophysiology and Transplantation; Università degli Studi di Milano; Milan, Italy; Internal Medicine; Fondazione IRCCS Ca’ Granda Ospedale Policlinico Milano; Milan, Italy; *Email: [email protected]; http://dx.doi.org/10.4161/cc.28754
منابع مشابه
Association between CDKN1A Ser31Arg and C20T gene polymorphisms and colorectal cancer risk and prognosis.
BACKGROUND CDKN1A (p21(WAF1/CIP1)) plays an important role in cell cycle regulation. Somatic alterations in genes which regulate cell division have been shown to be related to different types of cancer prognosis and survival. The purpose of this study was to investigate the effect of the CDKN1A Ser31Arg and C20T gene polymorphisms in Turkish patients with colorectal cancer. PATIENTS AND METHO...
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Invasive bladder cancer has high morbidity and nearly uniform mortality when metastatic, with no therapeutic improvement in many years. Although chemotherapy combined with Chk1 inhibition has been investigated in several cancer types in which TP53 mutation is seen, this combination treatment approach has not been studied in bladder cancer. Recently, cancer genome sequencing efforts have identif...
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Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the head and neck with the highest incidence rate in southern China. The aim of the present study was to understand the molecular mechanisms that underlie the progression of NPC. The relative expression of miR-93 and CDKN1A was detected by the reverse-transcription quantitative PCR. Western blot analysis was applied to detect the pro...
متن کاملExpression of CDKN1A/p21 and TGFBR2 in breast cancer and their prognostic significance.
BACKGROUND A new diagnostic and prognostic biomarker may be of value in cancer diseases. Our study aimed to evaluate the CDKN1A/p21 and TGFBR2 level measurable in a cohort of patients with breast cancer after mastectomy, and to confirm their suitability to serve as prognostic biomarkers of the cancer. METHODS The expression levels of CDKN1A/p21 and TGFBR2 were detected by reverse transcriptio...
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Experimental studies have shown that estrogen- or progesterone-activated signaling leads to growth inhibition effects on colon cancer cells through the upregulation of several cell-cycle regulators. However, epidemiologic studies evaluating hormone therapy use and colorectal cancer risk by the status of cell-cycle regulators are lacking. In this study, we used data from the prospective Nurses' ...
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This study was designed to discover blood biomarkers of cancer susceptibility using invasive multiple (n = 21), single primary breast cancer (n = 21), and control subjects (n = 20). Heparinized whole blood was incubated at 37 degrees C for 2 hours after 0-10 Gy of radiation, then cell cycle arrest marker CDKN1A and apoptosis marker BBC3 mRNA were quantified. This epidemiological study was pract...
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2014